May 2013

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AMCP Looks to the Future

Edith Rosato, RPh, began her position as AMCP’s chief executive officer in October 2011, coinciding with unprecedented change in the healthcare industry. Economic conditions were weak, and companies were preparing for provisions in the Patient Protection and Affordable Care Act (ACA).

The uncertainty remains due to the lingering effects of the recession and the ACA not fully being implemented until next year. Still, Ms. Rosato has taken steps to guide AMCP’s evolution and help its members stay abreast with the transformations.



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Hepatitis C Treatment Options Likely to Expand

San Diego—The FDA approvals of boceprevir and telaprevir in 2011 were seen as breakthroughs in treating patients with hepatitis C. The oral drugs are protease inhibitors used in combination with pegylated interferon and ribavirin. These therapeutic regimens are expensive, require several pills per day, and are only intended for genotype 1 disease.



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Healthcare Issues and Trends

San Diego—For the first time in 60 years, prescription drug sales declined in the United States in 2012, falling by 1%. At the same time, the number of prescriptions filled increased only 1.2% last year, according to data from IMS Health, a healthcare analytics company.

Douglas Long, MBA, vice president of industry relations at IMS Health, discussed the reasons behind the trend and shared other industry insights during a Contemporary Issues session at the AMCP meeting titled Emerging Issues and Trends in Healthcare and Managed Care Pharmacy.



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Multiple Sclerosis Treatment Options

San Diego—As the FDA approves more drugs to treat multiple sclerosis, healthcare professionals are attempting to understand the costs, benefits, and risks associated with the various treatment options.

Speakers discussed the therapies in a Satellite Symposium at the AMCP meeting titled The Evolution of Multiple Sclerosis Treatment: The Role of the Managed Care Pharmacist. The symposium was supported by an educational grant from Biogen Idec.



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Integrated Pharmacy Program

San Diego—The Medicaid system includes patients described as complex, who comprise a challenging and transient group of patients. Managing this group of patients in the face of complications including lack of claims data, high rates of nonadherence, frequent hospital admissions, and cultural challenges have led plans to develop new techniques such as integrated pharmacies that work directly with the health plans, providers, case workers, and others to help manage this complex patient population.



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Utilizing CER to Manage Rheumatoid Arthritis

San Diego—For managed care professionals, rheumatoid arthritis (RA) is among the most expensive and difficult diseases to manage. The FDA has approved several drugs to treat the disease, but it is sometimes hard to determine the option that would work best for patients.



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Site of Care May Impact Breast Cancer Management and Economic Outcomes

San Diego—Patients with nonmetastatic HER2+ breast cancer who were administered trastuzumab in an outpatient hospital setting incurred higher total monthly healthcare costs compared with patients treated in an office clinic, according to information presented during a poster session. They also had a higher incidence of nontrastuzumab-related outpatient hospital and office clinic visits.



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Payers’ Views on Specialty Pharmaceuticals Market

San Diego—Between 2007 and 2011, specialty drug costs grew from 15% to 20% each year, whereas spending on traditional drugs increased <5% each year, according to the Express Scripts 2011 drug trend report. Specialty drug spending is expected to grow ≥20% in the next 2 years, as well.



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Managed Care Strategies for Multiple Sclerosis

San Diego—In the United States, approximately 400,000 people have multiple sclerosis (MS). Each day, there are approximately 200 new diagnoses of the disease, presenting a burden on patients who typically live with MS for 20 to 40 years as well as the healthcare system that has to treat the chronic, costly condition.



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Switching from Oral to Intrauterine Contraception May Result in Cost Savings for Health Plans

San Diego—Switching oral contraceptive (OC) users to a low-dose levonorgestrel-intrauterine (LNG-IUS) system may result in overall cost savings for healthcare plans, due to subsequent decreases in pharmacy costs and a decrease in medical costs related to unintended pregnancies, according to information presented during a poster session at the AMCP meeting. The poster was titled Budget Impact of the Introduction of a Low-Dose Levonorgestrel-Intrauterine System from a US Third-Party Payer Perspective.



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Improving Part D Star Ratings through Collaboration

San Diego—The Centers for Medicare & Medicaid Services (CMS) Star Ratings program has heightened plan sponsors’ attention for the need to improve medication adherence and other aspects of medication use. As a result, plans will continue to have increased accountability associated with medication use quality measure performance. Pharmacies and pharmacists are well-positioned to be key partners in strategies aimed at improving the quality of medication use.



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Interventions Needed to Improve Adherence to Antiretroviral Therapy

San Diego—More than a quarter of patients with HIV treated with antiretroviral therapy (ART) do not adhere to therapy, according to a study presented during a poster session at the AMCP meeting. The poster was titled Adherence to Antiretroviral Therapy in Managed Care Members in the United States: A Retrospective Claims Analysis. The study also found that adherence was significantly improved in people who received a single-tablet-regimen (STR) of ART.



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Personalized Medicine: Changing the Paradigm for Value

San Diego—Personalized medicine is promising to revolutionize medical care by tailoring diagnostic and therapeutic approaches to individual patients based on an improved understanding of genetics and molecular biology. For pharmacists and pharmacy groups, this focus on personalized medicine will pose a number of challenges to delivering care. Among these will be issues regarding the economics of personalized medicine, including coding and reimbursement issues, as well as formulary management for high cost, targeted therapies.



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Self-injected SC versus IV Biologic Agents for RA

San Diego—Based on a new claims-based algorithm developed to evaluate the effectiveness of biologics for rheumatoid arthritis (RA), self-injected subcutaneous (SC) first-line biologic agents are more effective than intravenous (IV) administered agents in RA patients.



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A Member-Directed Medication Adherence Intervention

San Diego—Engaging patients and improving medication adherence was the aim of a program implemented in a population of dual-eligible special needs Medicare Advantage (MA) beneficiaries. The program involved the cooperation of a MA plan (iCare), a pharmacy benefit manager (MedImpact HealthCare Systems, Inc.), and a mail-order pharmacy (United States Medical Supply [US MED]).



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Utilization Patterns of Infliximab for RA

San Diego—An understanding of the current usage patterns of infliximab in the treatment of rheumatoid arthritis (RA) is a crucial component in the management of patients. Because real-world data of weight-based utilization patterns of this medication is limited, researchers examined the weight-based dosing and utilization patterns in infliximab-treated RA patients in a California ambulatory care network.



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Medicaid MCOs Face Challenges as Population Grows

San Diego—The Medicaid patient population is expected to grow under the Patient Protection and Affordable Care Act (ACA), leaving managed care organizations (MCOs) to face increasing challenges as they attempt to limit costs, particularly in the area of medication management. These challenges, current Medicaid trends, and future clinical issues expected to impact Medicaid MCOs were discussed at a Contemporary Issues session during the AMCP meeting.



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Costs for Medicare Patients Significantly Higher during Leucovorin Shortage

San Diego—The cost of care has significantly increased for Medicare patients taking leucovorin and/or Fusilev® (levoleucovorin) since the first leucovorin shortage in 2008, according to findings from a recent retrospective analysis presented during a poster session at the AMCP meeting. The poster was titled Impact of Leucovorin Shortage on Treatment Costs in Medicare Members.



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The Medical Moment of Truth Can Reduce Gaps in Care

San Diego—The best time for a physician and patient to decide on an effective, comprehensive, and manageable treatment plan is during the initial prescribing visit. This is, according to a Contemporary Issues session at the AMCP meeting, the medical moment of truth, which can make or break a patient’s pattern of medication adherence and set the tone for the efficacy of his or her treatment.



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Units and Costs of Comparable Insulin Supplied to Patients

San Diego—Many companies that supply insulin can offer products with similar pharmacokinetic or pharmacodynamic (PK/PD) properties. This is the case with the active ingredients of insulin products produced by Eli Lilly and Company (LLY) and Novo Nordisk (NN).



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Health Insurance Marketplace Launches Come with Challenges

San Diego—The challenges that come with the launch of the new health insurance marketplaces as 2014 rapidly approaches were topic for discussion in a Contemporary Issues session at the AMCP meeting titled Fostering Healthy Markets: Opportunities and Challenges with Launching Health Insurance Marketplaces. The presenters were Heather Bonome, PharmD, senior clinical account executive, Express Scripts; H.



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Health Outcomes Associated with Insulin after OAD Therapies

San Diego—Despite clinical practice that usually does not include the introduction of insulin therapy in patients newly diagnosed with type 2 diabetes mellitus (T2DM), most patients will eventually require treatment with insulin to maintain good glycemic control.



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Managed Care Organizations and Medicare Star Ratings

San Diego—The emerging model for healthcare in the United States is value-driven healthcare, according to speakers at a Contemporary Issues session at the AMCP meeting. The session was titled How Much of the $3 Billion in Star Rating Bonuses Did your MCO Capture? The first speaker, David Nau, RPh, PhD, CPHQ, FAPhA, president, Pharmacy Quality Solutions, opened the session by defining value as the balance of quality and costs, creating an environment in which healthcare providers can “optimize value by improving quality while reducing costs.”



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ACOs—A Model for Healthcare Reform

San Diego—Accountable care organizations (ACOs), included as part of the Patient Protection and Affordable Care Act, are groups of physicians, hospitals, and other healthcare providers who form an organization to provide coordinated quality care to Medicare beneficiaries, and share in any savings resulting from the alliance. It is estimated that 25 to 31 million Americans receive care from an ACO and 40% of Americans live in an area with at least 1 ACO.



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Pharmacy Benefits in Health Exchanges

San Diego—Currently, health plans are designing pharmacy benefits to be used in conjunction with the medical benefits for the state health exchanges. Successful health plans will engage pharmacists to improve the design and management of the individual and small group benefits. A panel of health plan pharmacists discussed the key features of pharmacy benefits related to health exchanges during a Contemporary Issues session at the AMCP meeting titled Essential Pharmacy Benefits for Individual and Small Group Insurance.



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Healthcare Resource Utilization after Initiation of a Triptan

San Diego—A new retrospective analysis of patients suffering from migraines found that the use of triptans did not decrease the utilization of healthcare resources, and, in some cases, was associated with an increase in utilization. These findings were recently presented during a poster session at the AMCP meeting. The poster was titled Healthcare Resource Utilization after Initiation of a Triptan.



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Federal and State Legislative Update

San Diego—The federal budget sequester struggle, the continuing movement toward the implementation of the Patient Protection and Affordable Care Act (ACA), and issues facing Medicare Part D are among the most significant legislative and regulatory proposals of interest to managed care pharmacy.



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Saxagliptin Less Costly in Specific Patient Populations

San Diego—Diabetes patients treated with saxagliptin were significantly less prone to inpatient hospitalizations or emergency department (ED) visits than patients treated with sulfonylureas. Total healthcare costs were also lower for the saxagliptin group. Study data were presented during a poster session at the AMCP meeting. The poster was titled Healthcare Resource Use and Cost Outcomes with Saxagliptin versus Sulfonylureas in Elderly and Renally Impaired Patients.



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Adherence to and Utilization of Antimuscarinic Agents for OAB

San Diego—Compared with other chronic conditions, national trends indicate that adherence to medications to treat overactive bladder (OAB) is relatively poor. Antimuscarinic medications, including oxybutynin, are commonly prescribed for OAB. The updated 2012 Beers List recommends against using oral antimuscarinics in patients ≥65 years of age due to the increased risks of symptoms such as constipation.



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SafeUseNow: A Prescriber Intervention Program

San Diego—According to statistics from the Centers for Disease Control and Prevention (CDC), nonmedical use of prescription drugs is the second leading cause of accidental death in the United States. In addition, an analysis conducted in February 2013 by investigators at the CDC found that 75.2% of pharmaceutical deaths involved opioids, either alone or in combination with other drugs.



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Adapting Decision Analytic Models to Provide New Perspective

San Diego—Existing healthcare decision models may not always address real-world needs of decision makers, according to information presented during a Contemporary Issues session at the AMCP meeting titled Adapting Decision Analytic Models to Meet the Needs of the Health System. The presenters were Steve Duff, MS, president, Veritas Health Economics Consulting; Joe Gricar, MS, president, Apo-MED; and Prakash Navaratnam, RPh, MPH, PhD, senior director, DataMed Solutions LLC.



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Bevacizumab Infusion in Office/Clinic versus Outpatient Hospital Setting

San Diego—According to researchers, declining health plan reimbursements for physician-administered chemotherapy may shift the population of oncology patients treated with infused chemotherapy from office/clinic settings to outpatient hospital facilities.



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Adherence to Desvenlafaxine Improved with Refill and Save Program

San Diego—The annual prevalence of major depressive disorder (MDD) in the United States is 7% and the lifetime prevalence rate is 16%. Patients with MDD experience depressed mood, fatigue, lack of interest in activities, insomnia or hypersomnia, and other symptoms that have a negative affect on productivity and quality of life.



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DMD Early Adherence as Predictor of Future Adherence

San Diego—Multiple sclerosis generally presents in young adults, resulting in a greater loss of productivity and quality of life compared with other diseases. Frequency of relapses can be reduced with use of disease-modifying drugs (DMDs), yet many patients struggle to maintain adherence to their DMD regimen. Adherence rates range from 28% to 87%, percentages that are similar to rates for medication regimens that require self-administration for other diseases.



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Expenditures in Patients Taking Noninsulin Antidiabetic Agents

San Diego—Healthcare decision makers face challenges in optimizing disease management in patients with type 2 diabetes mellitus (T2DM). Increasing healthcare expenditures can be attributed, in part, to the costs, including medical and pharmaceutical, associated with managing T2DM.



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Identifying the Economic Burden of Pain

San Diego—Pain is challenging to treat and the healthcare cost burden of pain is substantial. According to researchers, understanding the dynamics of the economic burden of pain will help providers and payers allocate resources more efficiently for improved management of various pain conditions.



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Rapidly Evolving Specialty Pharmacy Industry

San Diego—With the dominance of specialty drugs driving increasing prescription medication expenditures, pharmacists need to prepare for significant growth in specialty pharmaceuticals and its impact on medication benefit plans.



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Results of the EMD Serono Specialty Digest™, 9th Edition

San Diego—With major provisions from the Patient Protection and Affordable Care Act becoming effective next year, the healthcare industry is facing a challenge keeping medication costs in check due to, in part, the proliferation of expensive specialty drugs. To deal with the issue, health plans are taking numerous steps such as implementing utilization management techniques and increasing the emphasis on cost effectiveness and comparative effectiveness research.



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Guideline-Preferred ART Regimens for Patients with HIV

San Diego—In March 2012, the U.S. Department of Health & Human Services (HHS) issued guidelines for the use of antiretroviral therapy (ART) in patients with HIV that recommend 4 specific preferred ART regimens for ART-naïve patients. In spite of trials of the guideline-preferred regimens showing “optimal and durable virologic efficacy, favorable tolerability and toxicity profiles, and ease of use,” there is real-world evidence suggesting that some healthcare providers prescribe non-preferred ART.



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Rare Diseases and Orphan Drugs: Status, Reimbursement, and Management

San Diego—There are approximately 7000 diseases that are categorized as rare, but only 5% of those have approved treatments. The 1984 amendment to the Orphan Drug Act of 1983 (ODA) defined a rare disease as one that affects 200,000 people in the United States. Existing laws such as the ODA and the 2012 Food and Drug Administration Safety and Innovation Act (FDASIA) were designed to promote research into treatments for rare diseases.



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Auvi-Q™ for Type 1 Allergic Reactions and Anaphylaxis

San Diego—As many as 6 million people in the United States are at risk of anaphylaxis, and the prevalence is increasing, especially among people <20 years of age, according to several studies. In August 2012, the FDA approved Auvi-Q (epinephrine injection, USP) as an emergency treatment for type 1 allergic reactions, including anaphylaxis, to stinging and biting insects.



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Oral Medication Aubagio® Approved for Multiple Sclerosis

San Diego—In the past, patients with multiple sclerosis were required to administer medications intravenously or via injections, a painful process for some, but they had no other choices. Now, though, treatment options have expanded into oral drugs, including Aubagio® (teriflunomide).

David Brandes, MD, neurologist at the Hope Neurology Center in Knoxville, Tennessee,  discussed teriflunomide during a Product Theater at the AMCP meeting. Genzyme Corporation, a Sanofi company and the product’s manufacturer, sponsored the session.



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Three Ways to Improve Medication Nonadherence

San Diego—Medication nonadherence is a costly problem in healthcare, but predictive modeling, value-based insurance design (VBID), and the application of gamification could help improve adherence rates. These 3 strategies and the challenges surrounding nonadherence were discussed in detail in a Managed Care Essentials session at the AMPC meeting titled Emerging Solutions for Medication Nonadherence Management. The session was presented by Yelena Yankovskaya, PharmD, a managed markets fellow at the University of the Sciences in Philadelphia.