June 2011

New Demands and Initiatives for Providers under Healthcare Reform

Orlando—If healthcare costs rise as rapidly as projected, the United States will experience major financial ramifications, according to Gary Scott Davis, PA, partner in the health law department of McDermott Will & Emery, LLP.

At the NAMCP meeting, Mr. Davis said the United States spends $2.4 trillion on healthcare, representing 17% of the country’s gross domestic product. By 2016, Mr. Davis estimated spending would increase to $4.1 trillion, even without factoring in the costs related to the Patient Protection and Affordable Care Act (ACA).



Partnerships between Physicians and Hospitals

Orlando—President Barack Obama enacted the Patient Protection and Affordable Care Act (ACA) to improve the value of healthcare, with an emphasis on increasing the access of care, decreasing the cost escalation, and implementing quality measures. To help achieve those goals, physicians and hospitals must work together, according to Robert Lancey, MD, MBA, chief of cardiac surgery and codirector of the Heart Institute at the Bassett Heart Care Institute in Cooperstown, New York.



ACO Regulations Announced

Orlando—After several months of anticipation, healthcare professionals received some guidance regarding accountable care organizations (ACOs) on March 31 when the Centers for Medicare & Medicaid Services (CMS) announced proposed federal rules pertaining to ACOs. The 429-page document revealed numerous aspects of ACOs, such as an emphasis on quality, cost-savings, and care coordination.



Reducing Costs and Improving Outcomes in Diabetes

Orlando—With fewer physicians, rising healthcare costs, and an increasing population, treating patients is becoming more difficult. For instance, >24 million people in the United States ≥20 years of age have diabetes, and the total costs associated with disease were estimated at $218 billion in 2007, according to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).



Understanding, Assessing, and Treating Pain

Orlando—Patients experiencing chronic pain are a burden on the healthcare system from an economic perspective and in terms of high utilization of medicine. Each year, lost work productivity related to chronic pain costs an estimated $61.2 billion. Another study found that total annual costs of poorly controlled persistent pain are >$100 billion, according to Mark Rosenberg, MD, PhD, president of BHM Healthcare Solutions, a management consulting and advisory firm.



Improved Care and Reduced Costs Associated with Patient-Centered Medical Homes

Orlando—In recent years, 18 states have implemented a total of 27 large multistakeholder pilot programs examining patient-centered medical homes (PCMHs). The District of Columbia and 44 states have passed >330 laws related to PCMHs.



Early Diagnosis and Treatment in Patients with RA

Orlando—With the incidence of patients with rheumatoid arthritis (RA) increasing and the disease currently the leading cause of chronic disability per capita in the United States, healthcare professionals are seeking ways to achieve better outcomes. According to studies and RA experts, treating patients as soon as possible after they are diagnosed with RA leads to improved response to treatment as well as reduced comorbidities.



Latest Tracking Poll Shows Little Support for Changing Medicaid

The latest tracking poll (May 2011) conducted by the Henry J. Kaiser Family Foundation found that overall there is little public support for cutting Medicaid spending or changing the program to a block grant to reduce the federal deficit.

Only 13% of Americans say they would support major reductions in Medicaid spending to help reduce the deficit; only 3 in 10 say they would support minor reductions in the program. More than half (53%) say they want no reductions in Medicaid spending.



Treatment of Non–Small-Cell Lung Cancer with Erlotinib and Gefitinib

Non–small-cell lung cancer (NSCLC) is a common and often a challenging form of cancer to treat, but erlotinib and gefitinib could be effective treatment options—especially for patients who have tumors with gene mutations that activate the epidermal growth factor receptor (EGFR). A recent article in the New England Journal of Medicine [2011;364(10):947-955] explores the clinical evidence, use, and possible adverse effects of these 2 treatment options for patients with NSCLC.



Emphysema and Lung Volume in Smokers with Interstitial Lung Abnormalities

Chronic obstructive pulmonary disease (COPD) may be manifested by emphysematous destruction of the lung parenchyma and elevated measures of total lung capacity, conditions often associated with exposure to tobacco smoke. is increased awareness that smoking may also result in areas of increased lung density (interstitial lung ab-normalities) seen on high-resolution computer tomography (HRCT).



Intermediate versus High Dose of Cytarabine for Acute Myeloid Leukemia

For >30 years, acute myeloid leukemia (AML) has been treated with cytarabine. Initially, the drug was used in remission-induction therapy at a dose of 100 to 200 mg per square meter of body surface area. High-dose therapy was evaluated beginning in 1975; cytarabine was given at a dose of 3000 mg/m2 twice daily for 6 days. At the higher dose, patients with relapse had high response rates; there were promising results for newly diagnosed patients as well.



Prescription Drug Spending in 2008

The Agency for Healthcare Research and Quality (AHRQ) recently issued Statistical Brief #313 identifying the top 5 therapeutic classes of outpatient prescription drugs in 2008 for adults age ≥18 in terms of expenditures. AHRQ ranked metabolic agents, central nervous system agents, cardiovascular agents, gastrointestinal agents, and psychotherapeutic agents as the top 5 drug classifications. These drugs were ranked by total expenditures out of the 18 broad therapeutic drug classes defined in 2008.



Behavioral Health Screening Rate after Court-Mandated Program

The Task Force on Mental Health of the American Academy of Pediatrics has recently endorsed mental health screening in primary care as a way to help the effort to prevent mental health disorders for children and adolescents. Studies have shown that many parents arrive at a primary care visit with concerns about their children’s emotional condition. Other studies have found that 12% to 13% of children 4 to 16 years of age have significant psychological dysfunction.



Motivational Intervention with Parental Participation in Adolescent Alcohol Use

There have been various efforts to improve awareness and to reduce substance abuse among adolescents. Studies have shown that for 18- to 19-year-old adolescents, an individual motivational interview (IMI) effectively reduces alcohol-related problems. IMI is designed to empathize, offer personalized feedback, and show the negative effects of their drinking behavior on their goals. This type of individualized intervention decreased average drinking days and high-volume intake among 13- to 17-year-old alcohol users as well.



Nitroglycerin Ointment and Changes in Bone Mineral Density in Postmenopausal Women

As populations worldwide age, the number of osteoporotic fractures is increasing. Nitric oxide, an inexpensive and widely available treatment, may help limit the increase. The agent can inhibit osteoclast activity and act as a signaling molecule in osteoblasts and osteocytes. Observational studies have found that older women taking nitrates intermittently for angina have higher bone mineral density (BMD) at the hip compared with nonusers and with women taking it continuously.



Smoking in Midlife and the Long-Term Risk of Dementia

It is well known that smoking increases the risk of most diseases and death, but some studies suggest that smoking is also associated with a lower risk of certain neurodegenerative diseases, including Parkinson’s disease. Other studies have found a link between smoking and the risk of Alzheimer’s disease (AD), the most common form of dementia; some findings suggest that smoking reduces the risk of cognitive impairment.



Long-Term Bisphosphonate Use Associated with Greater Risk of Atypical Fractures

A large cohort study of women found that use of oral bisphosphonates for >5 years increased the risk of subtrochanteric or femoral shaft fractures, although the absolute risk of these fractures is low [JAMA. 2011;305(8):783-789]. Whereas studies have shown that bisphosphonates have become a mainstay of treatment for reducing the risk of osteoporotic fractures, concerns have recently emerged that bisphosphonate-related suppression of bone remodeling may adversely influence bone strength.



Study Finds Diabetes Associated with Premature Death from Cancer, Infectious Diseases

Diabetes mellitus is known to increase the risk of vascular diseases, but a new study found that diabetes is also associated with premature death from several forms of cancer, infectious diseases, external causes, intentional self-harm, and degenerative disorders. These latest findings were reported in the New England Journal of Medicine [2011;364(9):829-841].

While the association between diabetes and vascular diseases has been well documented, less is known about whether diabetes and hyperglycemia also increase the risk of death from cancer or other nonvascular diseases.



Medicaid Spending Trends over the Past Decade

The recent recession has had an impact on Medicaid spending, increasing monthly enrollment by the largest amount since the program was implemented. The Henry J. Kaiser Family Foundation’s Kaiser Commission on Medicaid and the Uninsured analyzed data on program enrollment from a survey of all 50 states conducted by Health Management Associates and found that the growth in Medicaid spending typically follows the trends of economic growth.



Lifestyle Intervention to Prevent Regain after Weight Loss

Overweight or obesity is a worldwide problem. An increased body mass index is associated with higher mortality, the development of coronary vascular disease, type 2 diabetes mellitus, certain types of cancer, gastrointestinal diseases, and arthritis. The impact of these diseases on healthcare costs highlights the need for strategies to address the problem, according to researchers.



Guideline for Inpatient Cellulitis and Abscess Reduces Use of Healthcare Resources

Results of a retrospective study that evaluated treatment of patients hospitalized for cellulites and abscess before and after implementation of a guideline to standardize care [Arch Intern Med. doi:10.1001/archinternmed.2011.29] found that implementation of the guideline led to shorter durations of more targeted antibiotic therapy and decreased use of healthcare resources.



The ClincalTrials.gov Results Database—Update and Issues

In use for more than a decade, the Clinical Trials.gov registry was expanded in 2008 to include a database for reporting results. The Food and Drug Administration Amendments Act (FDAAA) mandates that summary results data for certain trials of drugs, biologics, and devices be submitted to ClinicalTrials.gov whether published or not.



Diuretic Strategy and Renal Function in Acute Decompensated Heart Failure

A prospective, double-blind, randomized controlled study published in the March 3, 2011, issue of the New England Journal of Medicine [2011;364(9):797-805] found no differences in patients’ global assessment of symptoms or renal function with different strategies for furosemide administration in patients with acute decompensated heart failure. The DOSE (Diuretic Optimization Strategies Evaluation) study was conducted by the National Heart, Lung, and Blood Institute’s Heart Failure Clinical Research Network.



Hip Fracture and Long-Term Home Exercise Programs

There are >31,000 hip fracture cases per year in the United States, costing an estimated $14 million to $20 billion. The number of these cases is expected to rise to 700,000 in the United States and from 1.6 million currently worldwide to 4 million by 2050.



Inhaled Nitric Oxide in Episodes of Severe Pain in Patients with SCD

Sickle cell disease (SCD) is an autosomal-recessive disorder of the beta globin gene, in which mutant hemoglobin S polymerizes in erythrocytes, causing occlusion of the small blood vessels. The occlusion manifests clinically as episodes of severe pain (vaso-occlusive crisis [VOC]), damage to vital organs, and early death.



School-Based Asthma Intervention Significantly Improved Symptoms of Persistent Asthma in Urban Children

Results of a randomized trial [Arch Pediatr Adolesc Med. 2011;165(3):262-268] show that urban children with persistent asthma have significant improvement in symptoms when treated by a school-based asthma therapy intervention compared with the usual care treatment.



Secondary Prevention of CVD Events among Persons without Hypertension

Cardiovascular disease (CVD) represents 30% of all deaths worldwide and is the leading cause of death in the United States. Studies have shown a strong, graded, and independent association between blood pressure levels and the risk of CVD, stroke, and premature death. In people with prehypertension, 90% have at least 1 risk factor above optimal levels for heart disease or stroke and 68% had at least 1 clinically high risk factor for heart disease or stroke.



Use of Services among Young Adults with Autism Spectrum Disorders

In the United States, the number of students 12 to 17 years of age enrolled in special education with a diagnosis of autism spectrum disorder (ASD) increased from 15,480 in 1998 to 99,803 in 2007. Whether the increase is due to changing identification practices or a true increase in population prevalence, treated prevalence is increasing and, according to researchers, “implications of this trend for service systems are poorly understood.”



Standardized Dosing Could Help Patients Organize Medication Regimens

In the United States, physician prescriptions and labels on medications dispensed by pharmacies often include vague information outlining recommended medication schedules. The schedules are identified either in hourly intervals (every 4-6 hours) or times per day (twice daily). Previous studies have found that nearly 50% of patients misinterpreted common instructions when attempting to dose a single prescription medication.



REACH VA: A Dementia Caregiver Support Program

It is estimated that the 11 million caregivers in the United States providing 12.5 billion hours of care to individuals with Alzheimer’s disease are providing care valued at, but unpaid, nearly $44 billion. This unpaid value is in addition to long-term care costs of $178 billion (in 2006). The Institute of Medicine’s 2008 report, Retooling for an Aging America: Building the Health Care Workforce, stated that family members are an essential part of the healthcare workforce and should be given data, knowledge, and tools to provide high-quality care.



Benefits and Harms of Older Persons’ Willingness to Take Medications

Pay-for-performance and quality-assurance initiatives stress adherence to evidence-based guidelines for the prevention or management of particular diseases. Patient preferences, however, may not agree with the guidelines.



Characteristics of Adopters and Nonadopters of Personal Health Records

The Markle Foundation defines personal health records (PHRs) as an “Internet set of tools that allows people to access and coordinate their lifelong health information.” PHRs can range from applications maintained by healthcare organizations that build on a patient’s existing electronic record to stand-alone applications designed for the patient to use to supply the majority of the medical information to the PHR. The primary objective of a PHR, regardless of design, is to increase patient access to health information on a secure platform.



Tele-ICU Monitoring and Patient Outcomes

The presence of intensivists—physicians specially trained to care for critically ill patients—in intensive care units (ICUs) has been shown to improve survival, and there are estimates that staffing ICUs with intensivists 24 hours a day would save up to 50,000 lives and $4.3 billion in the United States each year. However, many hospitals do not have either the patient volume or financial resources to hire intensivists; in addition, there is a shortage of trained intensivists at this time.



Conflicts of Interest in Guideline Formation

Clinical practice guidelines (CPGs) are usually adopted as standard of care and taught as such in training programs for healthcare providers. CPGs are important in the development of initiatives to improve quality of care and are playing an emerging role in national policy on reimbursement; CPGs also serve as the standard of care in medical malpractice cases.



Hospital Spending and Patient Outcomes for Sepsis

Previous studies have found that regions of the United States with high rates of healthcare spending have poorer adherence to quality-of-care measures, worse clinical outcomes, and lower patient and physician satisfaction compared with low-cost areas. Current healthcare reform efforts have suggested that as much as one third of all government spending on healthcare could be eliminated without negatively affecting patient outcomes.



Survey Finds More Uninsured and Struggling to Pay Healthcare Costs in 2010

For many Americans, the economic recession has also meant a loss of health insurance or higher health-related costs, according to a new report from The Commonwealth Fund; however, the Affordable Care Act (ACA) is expected to address some of these concerns in coming years. These were just a few of the findings from The Commonwealth Fund 2010 Biennial Health Insurance Survey report.



Omalizumab Improves Asthma Control in Inner-City Youth

Results of a randomized, double-blind, placebo-controlled, multicenter trial [N Engl J Med. 2011;364(11):1005-1015] show that the addition of omalizumab to guidelines-based therapy improved asthma control, reduced the need for other medications to control asthma, and nearly eliminated seasonal peaks in exacerbations in inner-city children, adolescents, and young adults with persistent allergic asthma, with added benefit to those who also had allergies.



Quality of Life following PCI or CABG

Treatments for patients with multivessel coronary artery disease include percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). At the 1-year followup, the SYNTAX (Synergy between PCI with Taxus and Cardiac Surgery) trial found that the rate of composite primary end point (death, myocardial infarction, stroke, or repeat revascularization) was lower with CABG compared with PCI. The largest difference was in the need for repeat revascularization.



Treatments for Coronary Artery Disease and Left Ventricular Dysfunction

New Orleans—Combining coronary artery bypass grafting (CABG) with medical therapies for patients with coronary artery disease (CAD) and heart failure increased the overall risk of death for approximately 2 years after surgery compared with medication alone; however, in subsequent years, the rate of all-cause mortality in the CABG group dropped below the rate seen in the medication-only group, according to researchers with the STICH (Surgical Treatment for Ischemic Heart Failure) trial.



Radial versus Femoral Access for Invasive Coronary Procedures

New Orleans—A large randomized study has concluded that radial access is no less effective than femoral access for patients with acute coronary syndromes (ACS) who are undergoing procedures requiring vascular access, such as coronary angiography and percutaneous coronary intervention (PCI). The RIVAL (Radial vs Femoral Access for Coronary Intervention) trial also reported similar 30-day rates of adverse events with both approaches, with the exception of major vascular complications at the access site, which were significantly less likely to occur with radial access.



Transcatheter Aortic Valve Replacement Comparable with Surgery

New Orleans—A randomized study of patients with symptomatic aortic stenosis and at high risk for surgery found that those undergoing transcatheter aortic valve replacement (TAVR) had similar survival at 1 year compared with those undergoing aortic valve replacement (AVR), which is the standard of care. The authors noted that TAVR is the standard of care in patients who cannot undergo surgery, but that the results indicated that TAVR could also be an alternative to AVR in high-risk patients.



Percutaneous Mitral Valve Repair for Mitral Regurgitation

New Orleans—Through 2 years of treatment, patients who underwent percutaneous mitral valve repair had reduced mitral regurgitation (MR) and experienced meaningful clinical benefits, according to a randomized controlled trial that compared percutaneous mitral valve repair with surgery. The authors found that surgery provided more complete MR reduction, but percutaneous repair led to better safety.



Comparable Cost-Effectiveness with LAIV versus IIV Found in Young Children

Despite findings from a recent randomized controlled trial among young children that intranasal live attenuated influenza vaccine (LAIV) might cause an increase in adverse events (AEs) compared with the inactivated influenza vaccine (IIV), new research found that the cost-effectiveness of the 2 approaches remains comparable. The results of the study were published in the Archives of Pediatrics & Adolescent Medicine [2011;165(2):112-118].



Type 2 Diabetes Mellitus and Variants of the HMGA1 Gene

Type 2 diabetes mellitus (DM) is one of the most common metabolic disorders, affecting nearly 250 million people worldwide. It is associated with major diabetes-related complications, including retinopathy, nephropathy, neuropathy, and cardiovascular disease. Individuals with type 2 DM are resistant to endogenous and exogenous insulin; both genetic and environmental factors contribute to the onset of hyperglycemia.



Maternal Influenza Vaccination Associated with Flu Protection in Infants

Young infants born to mothers vaccinated against influenza while pregnant appear less likely to be infected with the flu or hospitalized for influenza-like illness (ILI) during the first 6 months of life, according to a study published in Archives of Pediatrics & Adolescent Medicine [2011; 165(2):104-111].



Study Finds Apixaban Reduces Stroke Risk in Atrial Fibrillation Patients

When compared with aspirin, apixaban, a factor Xa inhibitor, was found to significantly reduce the risk of stroke or systemic embolism in patients with atrial fibrillation who are not suitable for vitamin K antagonist therapy, according to a new double-blind study. The findings from the study were reported in the New England Journal of Medicine [2011;364(9):806-817].



Use of School-Based Health Centers May Prevent High School Dropout in Urban Teens

Urban high school students with low-to-moderate use of school-based health centers (SBHCs) may be at a decreased risk of dropout compared with those who do not use these services, according to a study published online in the Archives of Pediatrics & Adolescent Medicine [doi:10.001/archpediatrics.2011.10].